Biomedical NMR group

Name of the responsible structure

  • Pr. MALET-MARTINO Myriam

Guardianship of the structure

  • SPCMIB laboratory, UMR CNRS 5068 Toulouse University III (Paul Sabatier)

Referent person for trade with MetaboHUB

  • BALAYSSAC Stéphane


  • Université Toulouse III (Paul Sabatier) Bâtiment 2R1, 118 route de Narbonne, 31062 Toulouse cedex 09



By conventional NMR metabolomics for biomarker research.
Matrices: biological fluids (plasma, CSF, urine), cell extracts and tissue.
Pathology: cancers (melanoma, leukemia) Alzheimer's disease, Hypophosphatasia.


From the samples provided by the customers (fluids, cell pellets, fabrics, ...), the possible benefits are:
- Any sample preparation,
- Recording NMR spectra,
- Assignment of NMR signals (depending on the nature of the sample),
- NMR data processing (normalization, scaling).
- Statistical analysis of the data (Univariate, Multivariate supervised or unsupervised)
The results will be communicated to customers in the form of meeting and / or report.

Analytical capacity with the kind of mastered technical

The group can analyze fifty samples per month.


Bruker Avance 400 (BBI probe, TBO) with an autosampler NMRCase (24 positions).
Bruker Avance 500 (cryoprobe TCI) with a cooled autosampler SAMPLEJET.

Skills and Human Resources

Skills area :
- Analytical chemistry (mainly NMR),
- Metabolism: search for biomarkers of various pathologies,
- Methodological developments (sample processing, data, quantitative NMR box statistical tools),
Human ressources :
3 lecturers (2 Prof and 1 MCF)

Quality approach

Quality approach engaged: inventory sheet, life sheet, record of use, record anomaly / corrective action, record samples, procedures (sample preparation, acquisitions NMR spectra).