Année |
Titre de la
publication |
Auteurs |
Nom de la publication |
Site |
Référence |
Lien vers résumé |
2012 |
Anthocyanin identification and composition of wild Vitis spp. accessions by using LC-MS and LC-NMR |
Acevedo de la Cruz A, Hilbert G, Rivière C, Mengin V, Ollat N, Bordenave L, Decrocq S, Delaunay JC, ... |
Analytica Chimica Acta |
BMP |
732: 145-152 |
http://www.sciencedirect.com/science/article/pii/S000326701101628X |
2012 |
Telling Stories: Enumerating maximal directed acyclic graphs with a constrained set of sources and targets |
Acuña V, Etienne Birmelé E, Cottret L, Crescenzi P, Jourdan F, Lacroix V, Marchetti-Spaccamela A, Marino ... |
Theoretical Computer Science |
MetaTOUL |
457: 1-9 |
http://www.sciencedirect.com/science/article/pii/S0304397512007207 |
2012 |
Role of low-density lipoprotein receptor in the hepatitis C virus life cycle |
Albecka A, Belouzard S, Op de Beeck A, Descamps V, Goueslain L, Bertrand-Michel J, Tercé F, Duverlie ... |
Hepatology |
MetaTOUL |
55(4):998-1007 |
http://www.ncbi.nlm.nih.gov/pubmed/22121002 |
2012 |
YPR139c/LOA1 encodes a novel lysophosphatidic acid acyltransferase associated with lipid droplets and involved in TAG homeostasis |
Ayciriex S, Le Guédard M, Camougrand N, Velours G, Schoene M, Wattelet-Boyer V, Dupuy J-W, Shevchenko ... |
Molecular Biology of the Cell |
BMP |
23: 233-246 |
http://www.ncbi.nlm.nih.gov/pubmed/22090344 |
2012 |
(homo)glutathione deficiency impairs Meloidogine incognita development in Medicago truncatula |
Baldacci F, Chang C, Maucourt M, Deborde C, Hopkins J, Lecomte P, Bernillon S, Brouquisse R, Moing A, ... |
PLoS Pathogens |
BMP |
8: e1002471 |
http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1002471 |
2012 |
Exosomal lipids impact notch signaling and induce death of human pancreatic tumoral SOJ-6 cells |
Beloribi S, Ristorcelli E, Breuzard G, Silvy F, Bertrand-Michel J, Beraud E, Verine A, Lombardo D |
Plos One |
MetaTOUL |
7(10):e47480 |
http://www.ncbi.nlm.nih.gov/pubmed/?term=Exosomal+lipids+impact+notch+signaling+and+induce+death+of+human+pancreatic+tumoral+SOJ-6+cells |
2012 |
The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans |
Benhamed F, Denechaud PD, Lemoine M, Robichon C, Moldes M, Bertrand-Michel J, Ratziu V, Serfaty L, Housset ... |
Journal of Clinical Investigation |
MetaTOUL |
22(6):2176-94 |
http://www.ncbi.nlm.nih.gov/pubmed/?term=The+lipogenic+transcription+factor+ChREBP+dissociates+hepatic+steatosis+from+insulin+resistance+in+mice+and+humans |
2012 |
Reconstitution of plant alkane biosynthesis in yeast demonstrates that Arabidopsis CER1 and CER3 are core components of a VLC-alkane synthesis complex |
Bernard A, Domergue F, Pascal S, Jetter R, Renne C, Faure JD, Haslam RP, Napier JA, Lessire R, Joubès ... |
The Plant Cell |
BMP |
24: 1-13 |
http://www.plantcell.org/content/24/7/3106.full |
2012 |
Precautions for harvest, sampling, storage and transport of crop plant metabolomics samples |
Biais B, Bernillon S, Deborde C, Cabasson C, Rolin D, Tadmor Y, Burger J, Schaffer AA, Moing A (2012) ... |
In N Hardy, R Hall, eds, Plant Metabolomics. Humana Press, Totowa, U.S.A. |
BMP |
860: 51-63 |
http://www.ncbi.nlm.nih.gov/pubmed/22351170 |
2012 |
Electronic effects of 11? substituted 17?-estradiol derivatives and instrumental effects on the relative gas phase acidity. |
Bourgoin-Voillard S, Fournier F, Afonso C, Zins EL, Jacquot Y, Pèpe C, Leclercq G, Tabet JC. |
J Am Soc Mass Spectrom |
MetabolomeIDF |
23(12):2167-77 |
http://link.springer.com/article/10.1007%2Fs13361-012-0486-8 |
2012 |
Lipids of plant membrane rafts |
Cacas JL, Furt F, Le Guédard M, Schmitter J, Buré C, Gerbeau-Pissot P, Moreau P, Bessoule J, Simon-Plas ... |
Progress in Lipid Research |
BMP |
51: 272-299 |
http://www.ncbi.nlm.nih.gov/pubmed/22554527 |
2012 |
Rapid nanoscale quantitative analysis of plant sphingolipid long chain bases by GC-MS |
Cacas JL, Melser S, Domergue F, Joubès J, Bourdenx B, Schmitter JM, Mongrand S |
Analytical Bioanalytical Chemistry |
BMP |
403: 2745-2755 |
http://www.ncbi.nlm.nih.gov/pubmed/22576656 |
2012 |
Isotopic profiling of ¹³C-labeled biological samples by two-dimensional heteronuclear J-resolved nuclear magnetic resonance spectroscopy. |
Cahoreau E, Peyriga L, Hubert J, Bringaud F, Massou S, Portais JC. |
Analytical Biochemistry |
MetaTOUL |
427(2):158-63 |
http://www.ncbi.nlm.nih.gov/pubmed/22658961 |
2012 |
A genomics and multi-platform metabolomics approach to identify new traits of rice quality in traditional and improved varieties |
Calingacion MN, Boualaphanh C, Daygon VD, Anacleto R, Sackville Hamilton R, Biais B, Deborde C, Maucourt ... |
Metabolomics |
BMP |
8: 771-783 |
http://link.springer.com/article/10.1007/s11306-011-0374-4 |
2012 |
NMR metabolomic approaches for plants, toxicology and medicine |
Canlet C, Shintu L, Elena-Herrmann B |
Actualité Chimique |
MetaTOUL |
364: 59-68 |
http://WOS:000307795900014 |
2012 |
Characterization of maternal and fetal bisphenol A disposition in a physiologically-based sheep model |
Corbel T, Gayrard V, Viguie C, Puel S, Lacroix M Z, Toutain P L, Hagen-Picard N |
Journal of Veterinary Pharmacology and Therapeutics |
MetaTOUL |
35: 64 |
http://WOS:000310251900098 |
2012 |
Occurrence, biosynthesis and functions of N-acylphosphatidylethanolamines (NAPE): Not just precursors of N-acylethanolamines (NAE) |
Coulon D, Faure L, Salmon M, Wattelet V, Bessoule JJ |
Biochimie |
BMP |
94: 75-85 |
http://www.ncbi.nlm.nih.gov/pubmed/21575672 |
2012 |
N-Acylethanolamines and related compounds: aspects of metabolism and functions |
Coulon DF, Salmon M, Wattelet V, Bessoule J |
Plant Science |
BMP |
184: 129-140 |
http://www.ncbi.nlm.nih.gov/pubmed/22284717 |
2012 |
Elucidation by NMR solution of neurotensin in Small Unilamellar Vesicle environment: molecular surveys for neurotensin receptor recognition |
Da Costa G, Bondon A, Delalande O, Mouret L, Monti JP |
Journal of Biomolecular Structure and Dynamics |
BMP |
31: 809-817 |
http://www.ncbi.nlm.nih.gov/pubmed/22928939 |
2012 |
Exploring plant primary metabolism with MeRy-B a metabolomic database and knowledge base dedicated to plant |
Deborde C, Jacob D (2012) Exploring plant primary metabolism with MeRy-B a metabolomic database and ... |
In G Sriram, ed, Plant Metabolism: Methods and Protocols. Series: Methods in Molecular Biology, Vol. 1083 Humana Press |
BMP |
|
http://www.springer.com/life+sciences/plant+sciences/book/978-1-62703-660-3 |
2012 |
Arabidopsis wat1 (walls are thin1)-mediated resistance to the bacterial vascular pathogen, Ralstonia solanacearum, is accompanied by cross-regulation of salicylic acid and tryptophan metabolism. |
Denancé N, Ranocha P, Oria N, Barlet X, Rivière MP, Yadeta KA, Hoffmann L, Perreau F, Clément G, Maia-Grondard ... |
Plant Journal |
MetaTOUL |
15. doi: 10.1111/tpj.12027. |
http://dx.doi.org/10.1111/tpj.12027 |
2012 |
A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPAR?Biochimie |
Ducheix S, Podechard N, Lasserre F, Polizzi A, Pommier A, Murzilli S, Di Lisio C, D'Amore S, Bertrand-Michel ... |
Biochimie |
MetaTOUL |
95(3):556-67 |
http://www.ncbi.nlm.nih.gov/pubmed/?term=A+systems+biology+approach+to+the+hepatic+role+of+the+oxysterol+receptor+LXR+in+the+regulation+of+lipogenesis+highlights+a+cross-talk+with+PPAR%CE%B1Biochimie |
2012 |
Isorhapontigenin: a novel bioactive stilbene from wine grapes |
Fernández-Marín MI, Guerrero RF, García-Parrilla MC, Puertas B, Richard T, Rodriguez-Werner MA, Winterhalter ... |
Food Chemistry |
BMP |
135: 1353-1359 |
http://www.ncbi.nlm.nih.gov/pubmed/22953865 |
2012 |
Parallel Biotransformation of Tetrabromobisphenol A in Xenopus laevis and Mammals: Xenopus as a Model for Endocrine Perturbation Studies |
Fini J-B, Riu A, Debrauwer L, Hillenweck A, Le Mével S, Chevolleau S, Boulahtouf A, Palmier K, Balaguer ... |
Toxicological Sciences |
MetaTOUL |
125(2): 359-367 |
http://toxsci.oxfordjournals.org/content/125/2/359 |
2012 |
Trypacidin, a Spore-Borne Toxin from Aspergillus fumigatus, Is Cytotoxic to Lung Cells |
Gauthier T, Wang X, Sifuentes Dos Santos J, Fysikopoulos A, Tadrist S, Canlet C, Artigot M P, Loiseau ... |
PLoS ONE |
MetaTOUL |
7(2): e29906 |
http://dx.doi.org/10.1371%2Fjournal.pone.0029906 |
2012 |
Lipid rafts |
Germain V, Perraki A, Mongrand S (2012) |
In Enclycopedia of Life Science |
BMP |
DOI: 10.1002/9780470015902.a0023727 |
http://www.els.net/WileyCDA/ElsArticle/refId-a0023727.html |
2012 |
Flux analysis of the Trypanosoma brucei glycolysis based on a multi-objective criteria bioinformatic approach |
Ghozlane A, Bringaud F, Souedan H, Dutour I, Jourdan F, Thébault P |
Advances in Bioinformatics |
MetaTOUL |
2012:159423 |
http://www.hindawi.com/journals/abi/2012/159423/ |
2012 |
Aspects of experimental design for plant metabolomics experiments and guidelines for growth of plant material |
Gibon Y, Rolin D |
n N Hardy, R Hall, eds, Plant Metabolomics. Humana Press, Totowa, U.S.A. |
BMP |
860: 13-30 |
http://www.ncbi.nlm.nih.gov/pubmed/22351168 |
2012 |
New opportunities in metabolomics and biochemical phenotyping for plant systems biology |
Gibon Y, Rolin D, Deborde C, Bernillon S, Moing A |
In U Roessner, ed, Metabolomics. InTech |
BMP |
Jan-2029 |
http://www.intechopen.com/articles/show/title/new-opportunities-in-metabolomics-and-biochemical-phenotyping-for-plant-systems-biology |
2012 |
UFJCOSY: a fast 3D NMR method for measuring isotopic enrichments in complex samples. |
Giraudeau P, Cahoreau E, Massou S, Pathan M, Portais JC, Akoka S. |
ChemPhysChem |
MetaTOUL |
13(13):3098-101 |
http://www.ncbi.nlm.nih.gov/pubmed/22736503 |
2012 |
Cytotoxicity and genotoxicity of versicolorins and 5-methoxysterigmatocystin in A549 cells |
Jaksic D, Puel O, Canlet C, Kopjar N, Kosalec I, Klaric Maja S |
Archives of Toxicology |
MetaTOUL |
86(10): 1583-1591 |
http://dx.doi.org/10.1007/s00204-012-0871-x |
2012 |
Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test |
Khadra A, Pinelli E, Lacroix M Z, Bousquet-Melou A, Hamdi H, Merlina G, Guiresse M, Hafidi M |
Ecotoxicology and Environmental Safety |
MetaTOUL |
76: 187-192 |
http://www.sciencedirect.com/science/article/pii/S014765131100337X |
2012 |
Phenolics and their antifungal role in grapevine wood decay: focus on the Botryosphaeriaceae family |
Lambert C, Bisson J, Waffo-Teguo P, Papastamoulis Y, Richard T, Corio Costet MF, Mérillon JM, Cluzet ... |
Journal of Agricultural and Food Chemistry |
BMP |
60: 11859-11868 |
http://www.ncbi.nlm.nih.gov/pubmed/23145924 |
2012 |
Early changes in the fatty acid composition of photosynthetic membrane lipids from Populus nigra grown on a metallurgical landfill |
Le Guédard M, Faure O, Bessoule JJ |
Chemosphere |
BMP |
88: 693-698 |
http://www.ncbi.nlm.nih.gov/pubmed/22531865 |
2012 |
Soundness of in situ lipid biomarker analysis: Early effect of heavy metals on leaf fatty acid composition of Lactuca serriola |
Le Guédard M, Faure O, Bessoule JJ |
Environmental and Experimental Botany |
BMP |
76: 54-59 |
http://www.sciencedirect.com/science/article/pii/S0098847211002504 |
2012 |
Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver |
Marmugi A, Ducheix S, Lasserre F, Polizzi A, Paris A, Priymenko N, Bertrand-Michel J, Pineau T, Guillou ... |
Hepatology |
MetaTOUL |
55(2):395-407 |
http://www.ncbi.nlm.nih.gov/pubmed/?term=Low+doses+of+bisphenol+A+induce+gene+expression+related+to+lipid+synthesis+and+trigger+triglyceride+accumulation+in+adult+mouse+liver |
2012 |
Development of a liquid chromatography/atmospheric pressure photo-ionization high-resolution mass spectrometry analytical method for the simultaneous determination of polybrominated diphenyl ethers and their metabolites: application to BDE-47 metabolism i |
Marteau C, Chevolleau S, Jouanin I, Perdu E, De Sousa G, Rahmani R, Antignac J-P, LeBizec B, Zalko D, ... |
Rapid Communications in Mass Spectrometry |
MetaTOUL |
26(6): 599-610 |
http://dx.doi.org/10.1002/rcm.6136 |
2012 |
Photobioreactor design for isotopic non-stationary 13C-metabolic flux analysis (INST 13C-MFA) under photoautotrophic conditions. |
Martzolff A, Cahoreau E, Cogne G, Peyriga L, Portais JC, Dechandol E, Le Grand F, Massou S, Gonçalves ... |
Biotechnology and Bioengineering |
MetaTOUL |
109(12):3030-40 |
http://www.ncbi.nlm.nih.gov/pubmed/22688667 |
2012 |
IsoCor: correcting MS data in isotope labeling experiments. |
Millard P, Letisse F, Sokol S, Portais JC. |
Bioinformatics |
MetaTOUL |
28(9):1294-6 |
http://www.ncbi.nlm.nih.gov/pubmed/22419781 |
2012 |
ATP synthesis-coupled and -uncoupled acetate production from acetyl-CoA by mitochondrial acetate:succinate CoA-transferase and acetyl-CoA thioesterase in Trypanosoma. |
Millerioux Y, Morand P, Biran M, Mazet M, Moreau P, Wargnies M, Ebikeme C, Deramchia K, Gales L, Portais ... |
The Journal of Biological Chemistry |
MetaTOUL |
287(21):17186-97 |
http://www.ncbi.nlm.nih.gov/pubmed/22474284 |
2012 |
Down-regulation of a single auxin efflux transport protein in tomato induces precocious fruit development |
Mounet F, Moing A, Kowalczyk M, Rohrmann J, Petit J, Garcia V, Maucourt M, Yano K, Deborde C, Aoki K, ... |
Journal of Experimental Botany |
BMP |
63: 4901-4917 |
http://jxb.oxfordjournals.org/content/early/2012/07/25/jxb.ers167.full |
2012 |
Link between intestinal CD36 ligand binding and satiety induced by a high protein diet in mice |
Naville D, Duchampt A, Vigier M, Oursel D, Lessire R, Poirier H, Niot I, Bégeot M, Besnard P, Mithieux ... |
PLoS ONE |
BMP |
7: e30686 |
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0030686 |
2012 |
Differential Effects of Bisphenol A and Diethylstilbestrol on Human, Rat and Mouse Fetal Leydig Cell Function |
N'Tumba-Byn T, Moison D, Lacroix M, Lecureuil C, Lesage L, Prud'homme S M, Pozzi-Gaudin S, Frydman R, ... |
PLoS ONE |
MetaTOUL |
7(12): e51579 |
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0051579 |
2012 |
Metabolic Fate of 2,4-Dichlorophenol and Related Plant Residues in Rats |
Pascal-Lorber S, Despoux S, Jamin E L, Canlet C, Cravedi J-P, Laurent F |
Journal of Agricultural and Food Chemistry |
MetaTOUL |
60(7): p. 1728-1736 |
http://dx.doi.org/10.1021/jf203666k |
2012 |
Plasma membrane localization of Solanum tuberosum remorin from Group 1, Homolog 3 is mediated by conformational changes in a novel C-terminal anchor and required for the restriction of Potato Virus X movement |
Perraki A, Cacas J-L, Crowet J-M, Lins L, Castroviejo M, German-Retana S, Mongrand S, Raffaele S |
Plant Physiology |
BMP |
160: 624-637 |
http://www.ncbi.nlm.nih.gov/pubmed/22855937 |
2012 |
Co-consumption of methanol and succinate by Methylobacterium extorquens AM1. |
Peyraud R, Kiefer P, Christen P, Portais JC, Vorholt JA. |
PLoS One |
MetaTOUL |
7(11):e48271 |
http://www.ncbi.nlm.nih.gov/pubmed/23133625 |
2012 |
Integration of pharmacokinetic and pharmacodynamic data for tulathromycin in healthy and pneumonic calves |
Potter TJ, Illambas J, Rycroft A, Toutain PL, Lacroix MZ, Lees P |
Journal of Veterinary Pharmacology and Therapeutics |
MetaTOUL |
35:76 |
http://WOS:000310251900098 |
2012 |
Integration of pharmacokinetic and pharmacodynamic data for amoxicillin in healthy and pneumonic calves |
Potter TJ, Illambas J, Rycroft A, Toutain PL, Lacroix MZ, Lees P |
Journal of Veterinary Pharmacology and Therapeutics |
MetaTOUL |
35:76 |
http://WOS:000310251900098 |
2012 |
Novel fragmentation pathways of anionic adducts of steroids formed by electrospray anion attachment involving regioselective attachment, regiospecific decompositions, charge-induced pathways, and ion-dipole complex intermediates. |
Rannulu NS, Cole RB |
J Am Soc Mass Spectrom |
MetabolomeIDF |
23(9):1558-68 |
http://link.springer.com/article/10.1007%2Fs13361-012-0422-y |
2012 |
Phenotypic prediction based on metabolomic data for growing pigs from three main European breeds |
Rohart F, Paris A, Laurent B, Canlet C, Molina J, Mercat M J, Tribout T, Muller N, Iannuccelli N, Villa-Vialaneix ... |
Journal of Animal Science |
MetaTOUL |
90(13): p. 4729-4740 |
http://journalofanimalscience.org/content/90/13/4729.abstract?sid=764a816d-db9c-4bb5-a62d-7738a9678fa0 |
2012 |
Contribution of the nuclear receptors PXR and CAR to gene expression modulations induced by fipronil in rodent liver |
Roques B, Lacroix MZ, Moussaoui N, Leghait J, Puel S, Lasserre F, Guillou H, Viguié C, Martin P |
Journal of Veterinary Pharmacology and Therapeutics |
MetaTOUL |
35:43-44 |
http://WOS:000310251900098 |
2012 |
CYP450-dependent biotransformation of the insecticide fipronil into fipronil sulfone can mediate fipronil-induced thyroid disruption in rats |
Roques B B, Lacroix M Z, Puel S, Gayrard V, Picard-Hagen N, Jouanin I, Perdu E, Martin P G, Viguié C |
Toxicological Science |
MetaTOUL |
127(1): p. 29-41 |
http://toxsci.oxfordjournals.org/content/127/1/29 |
2012 |
Annotation of the human adult urinary metabolome and metabolite identification using ultra high performance liquid chromatography coupled to a linear quadrupole ion trap-orbitrap mass spectrometer |
Roux A, Xu Y, Heilier JF, Olivier MF, Ezan E, Tabet JC, Junot C. |
Analytical Chemistry |
MetabolomeIDF |
84(15):6429-37 |
http://pubs.acs.org/doi/abs/10.1021/ac300829f |
2012 |
TNF? gene knockout differentially affects lipid deposition in liver and skeletal muscle of high-fat-diet mice |
Salles J, Tardif N, Landrier JF, Mothe-Satney I, Guillet C, Boue-Vaysse C, Combaret L, Giraudet C, Patrac ... |
Journal of Nutritional Biochemistry |
MetaTOUL |
23(12):1685-93 |
http://www.ncbi.nlm.nih.gov/pubmed/?term=TNF%CE%B1+gene+knockout+differentially+affects+lipid+deposition+in+liver+and+skeletal+muscle+of+high-fat-diet+mice |
2012 |
Towards interoperable bioscience data |
Sansone S-A, Rocca-Serra P, Field D, E. Maguire CT, W. Hide,, O. Hofmann HF, S. Neumann, W. Tong, L. ... |
Nature Genetics |
BMP |
44: 121-126 |
http://www.ncbi.nlm.nih.gov/pubmed/22281772 |
2012 |
The ethylmalonyl-CoA pathway is used in place of the glyoxylate cycle by Methylobacterium extorquens AM1 during growth on acetate |
Schneider K, Peyraud R, Kiefer P, Christen P, Delmotte N, Massou S, Portais JC, Vorholt JA |
The Journal of Biological Chemistry |
MetaTOUL |
287(1):757-66 |
http://www.ncbi.nlm.nih.gov/pubmed/22105076 |
2012 |
influx_s: increasing numerical stability and precision for metabolic flux analysis in isotope labelling experiments. |
Sokol S, Millard P, Portais JC. |
Bioinformatics |
MetaTOUL |
28(5):687-93 |
http://www.ncbi.nlm.nih.gov/pubmed/22210866 |
2012 |
Distinctive gas-phase fragmentation pathway of the mitorubramines, novel secondary metabolites from Hypoxylon fragiforme. |
Svilar L, Stankov-Jovanovic V, Stadler M, Nedev H, Tabet JC |
Rapid Commun Mass Spectrom |
MetabolomeIDF |
26(22):2612-8 |
http://onlinelibrary.wiley.com/doi/10.1002/rcm.6382/abstract,jsessionid=6F96EFCEDF61D7D6AC661E7E51993AA2.f04t02 |
2012 |
High-resolution mass spectrometry and hydrogen/deuterium exchange study of mitorubrin azaphilones and nitrogenized analogues. |
Svilar L, Stankov-Jovanovic V, Lesage D, Dossmann H, Tabet JC. |
J Mass Spectrom |
MetabolomeIDF |
47(8):969-77 |
http://onlinelibrary.wiley.com/doi/10.1002/jms.3044/abstract |
2012 |
Evaluation of three simple direct or indirect carbonyl detection methods for characterization of oxidative modifications of proteins |
Vasquez-Garzon V R, Rouimi P, Jouanin I, Waeg G, Zarkovic N, Villa-Trevino S, Guéraud F |
Toxicology Mechanisms and Methods |
MetaTOUL |
22(4): 296-304 |
http://informahealthcare.com/doi/abs/10.3109/15376516.2012.657258 |