Sites and locations

Members of MetaboHUB

The MetaboHUB infrastructure is distributed on 4 sites in France indicated by the pictogram : .

The MetaboHUB infrastructure is distributed over 4 sites in France

La "Plateforme Métabolome Bordeaux" (BMP)The  "Bordeaux Metabolome platform" (BMP) is a metabolomics facility (IBiSA and INRA-Strategic-Platform labeled since 2008) dedicated to plant functional genomics, plant genetics and breeding, plant-pathogen/pest relationships and plant ecophysiology. BMP is devoted mostly to plant samples or plant-derived samples. BMP offers services or research collaborations to public and private research partners for the acquisition and interpretation of metabolomics and lipidomics profiles, the identification and/or the analysis of metabolites (NMR, MS), and the measurements of isotopic enrichment. Training and technological developments are other activities of the platform. Bordeaux Metabolome Facility has been approved by LRQA to the ISO 9001:2008 Quality Management System Standard.

In the scope of MetaboHUB, BMP intents to widen the metabolomics/lipidomics targeted or untargeted profiling methods proposed so far for plant samples and identify new plant compounds. MetaboHUB will allow (i) implementing targeted LC-MS quantification of low concentration metabolites, (ii) developing high-throughput MS lipid profiling, (iii) facilitating and speeding up metabolite identification in non-targeted metabolomics and lipidomics analyses, (iv) developing new expertise on metabolomics analysis at subcellular level and on metabolics networks, (v) following up the development of spectral and knowledge databases initiated in previous projects.

Photographe © Thomas Sanson

​La plateforme "Exploration du Métabolisme" (PFEM, Clermont-Ferrand) The Platform "Exploration du Métabolisme" (PFEM, Clermont-Ferrand) is the major national platform in metabolomics to invest in exploration of the effects of foods and nutrients on main physiological functions in human and animal, as well as exploration of environmental compartments and threatening. It provides to the scientific community, concepts, tools and methods in the emerging field of global analysis of metabolism in order to analyze the metabolic diet's effects, to identify and quantify new biomarkers linked to the nutritional status and to improve the early diet associated disease diagnostics. 

PFEM gained the IBiSA label in 2010. PFEM is dedicated to metabolic studies, from very detailed biochemical mechanisms to global metabolomics approaches.
In the framework of MetaboHUB, PFEM aims at: (i) enhancing the analysis rapidity and the robustness of metabolite identification in various biofluids (ii) facilitating metabolite identification and quantification in non-targeted metabolomics analyses in order to discover biomarkers of endogen metabolism dysfunction and food consumption, (iii) producing spectra databases and upgrading data mining tools development initiated in previous projects, (iv) developing new expertise in combined metabolomics-fluxomics analysis.

The plateform MetabolomeIDF (Ile de France, Paris-Saclay) platform is a multi-site platform dedicated to atmospheric pressure ionization-mass spectrometry (API-MS) based metabolomics and data processing, analysis and annotation. MetabolomeIDF brings its knowledge and experience in mass spectrometry based analysis of human biofluids and cell extracts for biomarker discovery to the MetaboHUB consortium. It aims to participate in large epidemiological cohorts and in clinical studies. In the framework of MetaboHUB, MetabolomeIDF will help to develop quantitative metabolomics, building relational databases of metabolites and metabolic signatures in biofluids in various physiological and pathological conditions, and will underpin the use of metabolomics in clinical laboratories for a qualitatively better medical follow-up of patients. MetabolomeIDF is also characterized by its competences in the development of algorithms and software tools required for the signal processing, multivariate data analysis and data mining of high resolution LC-MS data for metabolomics, and for their integration with other “omics” platforms for biomarker discovery, detection of alerts, robust clinical signatures, etc. (e.g. AgriFood GPS Oseo project and Biomargin FP7 European project).

Crédits : P. Stroppa/CEA, L. Godart/CEA 
The ​MetaToulMetaToul Platform is a multisite Metabolomics & Fluxomics Platform that merges the expertise and facilities in the field of metabolomics of 4 laboratories located in Toulouse. It gained IBiSA label in 2009 and is considered as an INRA ‘Strategic Platform’. MetaToul provides NMR & MS equipments, tools, and expertise for two fields of research: 1) microbiology and host/micro-organism interactions and 2) health & food safety. 

Due to the complementary expertise (biochemistry, analytical chemistry, biophysics, bioinformatics, biomathematics) and analytical tools included in the partnership, MetaToul can provide the scientists with a broad range of expertise and services in the emerging domain of metabolomics : i) targeted or large-scale analysis of metabolites, including their structural analysis; ii) identification and analysis of metabolic pathways and metabolic networks; iii) measurement of metabolic fluxes; and iv) chemometrics, metabolic phenotyping and biomarker identification. The services are very diverse in time & efforts, ranging from routine metabolite analyses to extensive development, validation and application of state-of-the-art MS or NMR methods.